From Wikipedia, the free encyclopedia
Jump to navigation Jump to search


Ksheka, you're fantastic. Btw, I've uploaded a new version of the image that is actually 275px wide, to it will render better in the browser.
You mention the ARREST trial, but I get the impression you're confusing the study quoted with another trial in The Netherlands (this one is American) which used similar methodology (police cars with defibrillators). I actually worked in the hospital where Dr Koster was running the ARREST trial, and one of my colleauges was a data collector there. JFW | T@lk 11:04, 19 May 2004 (UTC)

Thanks for the compliment. I really want to spruce up the different uses of amiodarone, and eventually talk about the use of amiodarone in individuals instead of a defibrillator... Ksheka
I'm pretty sure I got the correct study - I wanted to talk about the use of amiodarone to improve survival in a cardiac arrest situation. When I did a medline search for "Koster arrest", I only got one relevant result, which isn't what I was looking for. A search for "Koster amiodarone" gives a single hit which isn't relevant. If you can find a better study, please point me to it. Ksheka 13:24, May 19, 2004 (UTC)

No, I meant that the amiodarone trial wasn't called ARREST (I skimmed through the NEJM fulltext, but the word wasn't mentioned anywhere!) The ARREST (later also ARRESUST) trial in Amsterdam was published in the BMJ in 2003 (here). JFW | T@lk 14:26, 19 May 2004 (UTC)

Ahh...I understand the confusion now. You're saying that the ARREST trial has nothing to do with amiodarone. I got that name from "Cardiovascular Trials Review, 6th Edition" by Kloner & Birnbaum (The local Pfizer rep gave me a copy). I guess it's just one of those times when multiple trials have the same acronym. This article refers to the one I cited as ARREST. Ksheka 14:57, May 19, 2004 (UTC)

Okay, this explains everything. I'm still wondering, though, why the Kudenchuk article does not contain ARREST (in capitals) in its whole fulltext! Never mind... PS the Pfizer rep can't be wrong :-) JFW | T@lk 19:55, 19 May 2004 (UTC)

ARREST and ALIVE, where two trials used to analyze resuscitation rates in pre-hospital setting; which tested the efficacy of amiodarone in v-fib/v-tach pulseless patients, refractory to defibrillation.


Amiodarone. This page has many errors embedded into it. —Preceding unsigned comment added by (talk) 17:05, 21 October 2009 (UTC)

What an excellent drug. I took it for about three years then developed Hyperthyroidism. Not the safest way to loose weight.

When I first started taking the drug I had to go through the "loading" period. I was miserable and going into 240+ bpm VT in the morning and evening like clockwork.

I didn't seem to have any problem with Amiodarone orally so we tried to run it in through IV for faster loading. I felt the chemicals go in and immediately started to go into anaphylactic shock.

My fear is that I will be in a situation where I cannot direct emergency services to use something like lidocain instead of Ammiodarone IV. in fact it already happened once. Fortunatley my wife was there.

In any of the studies you mentioned, where there any other instances of patients having a hard time with Amiodarone IV?

I am suspecting it is not actually the ammiodarone but the solution it is suspended in. Do you have any idea what that is? I noticed they always come in glass containers.

What can I do to insure that this does not happen to me? I have a Medic alert necklace that I wear but the Emergency services and hospitals don't seem to notice it.

Are there ay other drugs or combinations of them that I can use to replace the amiodarone?

Currently I take Flecainide and Toprol but my life has not been as good as it was with Amiodarone.

Any more news with dronaderone or Azimalide?




Peter Zimetbaum has reviewed the use in AF - PMID 17329700. JFW | T@lk 00:07, 9 March 2007 (UTC)

Amiodarone may be a useful drug, but it's not without it's dangers. My Father died from liver failure - pseudo-alcoholic cirrhosis caused by taking ARATAC (the brand name for amiodarone in Australia). I'm going to document the information about this, so I'm building a website as a warning to others.

The article already mentions liver damage. JFW | T@lk 07:34, 23 September 2007 (UTC)


PMID 17878423 (JAMA 2007) reviews indications and followup. JFW | T@lk 07:34, 23 September 2007 (UTC)

Well-written article. Most accents in right places. —Preceding unsigned comment added by Gor n bein (talkcontribs) 19:15, 30 October 2007 (UTC)

You mean the Wikipedia article or PMID 17878423? And which accents are not in the right place?JFW | T@lk 19:57, 30 October 2007 (UTC)

Drug Interactions: P-GP Inhibition[edit]

This drug inhibits P-glycoproteins, so it has interactions with any drugs that are substrates for P-glycoproteins. I'm sure there are plenty of sources available to demonstrate this. —Preceding unsigned comment added by (talk) 09:50, 24 September 2010 (UTC)


The section on excretion contains many apparent references to "package insert". Are these citations, and if so is there a better way to document these? —Preceding unsigned comment added by (talk) 02:24, 3 March 2011 (UTC)

Gleb von Anrep[edit]

Gleb von Anrep is quoted as being Lebanese. It seem to bo be Russian  with german ascent. (see "Anrep effect" or "Anrep familly" in WP).  — Preceding unsigned comment added by (talk) 13:59, 3 October 2013 (UTC) 

Assessment comment[edit]

The comment(s) below were originally left at Talk:Amiodarone/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

On the External Links, please add

an FDA website that has additonal reported info [dated FDA Alerts] on this (amiodarone) and other drugs.

Please note amiodarone has NOT passed any FDA trials, and the recent Alerts indicate it is scary!

Last edited at 03:41, 18 May 2007 (UTC). Substituted at 07:36, 29 April 2016 (UTC)

Contradictory content[edit]

I have removed the following text from the article until the contradiction can be resolved.

In 1995, amiodarone was approved for the treatment of atrial fibrillation as an injection for intravenous use.<ref>{{Cite journal|last=Herendael|first=Hugo Van|year=2010|title=Amiodarone for the treatment and prevention of ventricular fibrillation and ventricular tachycardia|url=|journal=Vascular Health and Risk Management|volume=|pages=465–472|via=}}</ref> Amiodarone was not approved by any regulatory authority for the treatment of atrial fibrillation neither in intravenous nor oral form.  The reference doesn’t support the statement.

I don't have access the the reference, so I can't verify it one way or another. Perhaps someone else can have a look. -- Ed (Edgar181) 16:08, 7 February 2018 (UTC)